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Experimental Design for Laboratory Biologists

Author: Stanley E. Lazic

Publisher: Cambridge University Press

Published: 2016-12-08

Total Pages: 429

ISBN-13: 1316810674

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Specifically intended for lab-based biomedical researchers, this practical guide shows how to design experiments that are reproducible, with low bias, high precision, and widely applicable results. With specific examples from research using both cell cultures and model organisms, it explores key ideas in experimental design, assesses common designs, and shows how to plan a successful experiment. It demonstrates how to control biological and technical factors that can introduce bias or add noise, and covers rarely discussed topics such as graphical data exploration, choosing outcome variables, data quality control checks, and data pre-processing. It also shows how to use R for analysis, and is designed for those with no prior experience. An accompanying website (https://stanlazic.github.io/EDLB.html) includes all R code, data sets, and the labstats R package. This is an ideal guide for anyone conducting lab-based biological research, from students to principle investigators working in either academia or industry.

Book Synopsis Experimental Design for Laboratory Biologists by : Stanley E. Lazic

Download or read book Experimental Design for Laboratory Biologists written by Stanley E. Lazic and published by Cambridge University Press. This book was released on 2016-12-08 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Specifically intended for lab-based biomedical researchers, this practical guide shows how to design experiments that are reproducible, with low bias, high precision, and widely applicable results. With specific examples from research using both cell cultures and model organisms, it explores key ideas in experimental design, assesses common designs, and shows how to plan a successful experiment. It demonstrates how to control biological and technical factors that can introduce bias or add noise, and covers rarely discussed topics such as graphical data exploration, choosing outcome variables, data quality control checks, and data pre-processing. It also shows how to use R for analysis, and is designed for those with no prior experience. An accompanying website (https://stanlazic.github.io/EDLB.html) includes all R code, data sets, and the labstats R package. This is an ideal guide for anyone conducting lab-based biological research, from students to principle investigators working in either academia or industry.

Experimental Design for Laboratory Biologists

Author: Stanley E. Lazic

Publisher: Cambridge University Press

Published: 2016-12-08

Total Pages: 429

ISBN-13: 1107074290

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A guide to designing lab-based biological experiments that have low bias, high precision and widely applicable results.

Book Synopsis Experimental Design for Laboratory Biologists by : Stanley E. Lazic

Experimental Design for Biologists

Author: David J. Glass

Publisher: CSHL Press

Published: 2007

Total Pages: 211

ISBN-13: 0879697350

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The effective design of scientific experiments is critical to success, yet graduate students receive very little formal training in how to do it. Based on a well-received course taught by the author, Experimental Design for Biologistsfills this gap. Experimental Design for Biologistsexplains how to establish the framework for an experimental project, how to set up a system, design experiments within that system, and how to determine and use the correct set of controls. Separate chapters are devoted to negative controls, positive controls, and other categories of controls that are perhaps less recognized, such as â€œassumption controlsâ€ and â€œexperimentalist controlsâ€ . Furthermore, there are sections on establishing the experimental system, which include performing critical â€œsystem controlsâ€ . Should all experimental plans be hypothesis-driven? Is a question/answer approach more appropriate? What was the hypothesis behind the Human Genome Project? What color is the sky? How does one get to Carnegie Hall? The answers to these kinds of questions can be found in Experimental Design for Biologists. Written in an engaging manner, the book provides compelling lessons in framing an experimental question, establishing a validated system to answer the question, and deriving verifiable models from experimental data. Experimental Design for Biologistsis an essential source of theory and practical guidance in designing a research plan.

Book Synopsis Experimental Design for Biologists by : David J. Glass

Download or read book Experimental Design for Biologists written by David J. Glass and published by CSHL Press. This book was released on 2007 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: The effective design of scientific experiments is critical to success, yet graduate students receive very little formal training in how to do it. Based on a well-received course taught by the author, Experimental Design for Biologistsfills this gap. Experimental Design for Biologistsexplains how to establish the framework for an experimental project, how to set up a system, design experiments within that system, and how to determine and use the correct set of controls. Separate chapters are devoted to negative controls, positive controls, and other categories of controls that are perhaps less recognized, such as â€œassumption controlsâ€ and â€œexperimentalist controlsâ€ . Furthermore, there are sections on establishing the experimental system, which include performing critical â€œsystem controlsâ€ . Should all experimental plans be hypothesis-driven? Is a question/answer approach more appropriate? What was the hypothesis behind the Human Genome Project? What color is the sky? How does one get to Carnegie Hall? The answers to these kinds of questions can be found in Experimental Design for Biologists. Written in an engaging manner, the book provides compelling lessons in framing an experimental question, establishing a validated system to answer the question, and deriving verifiable models from experimental data. Experimental Design for Biologistsis an essential source of theory and practical guidance in designing a research plan.

Experimental Design and Data Analysis for Biologists

Author: Gerald Peter Quinn

Publisher: Cambridge University Press

Published: 2002-03-21

Total Pages: 560

ISBN-13: 9780521009768

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Regression, analysis of variance, correlation, graphical.

Book Synopsis Experimental Design and Data Analysis for Biologists by : Gerald Peter Quinn

Download or read book Experimental Design and Data Analysis for Biologists written by Gerald Peter Quinn and published by Cambridge University Press. This book was released on 2002-03-21 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regression, analysis of variance, correlation, graphical.

Experimental Design for the Life Sciences

Author: Graeme D. Ruxton

Publisher:

Published: 2023

Total Pages: 0

ISBN-13: 9780191975202

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Providing students with clear and practical advice on how best to organise experiments and collect data so as to make the subsequent analysis easier and their conclusions more robust, this text assumes no specialist knowledge.

Book Synopsis Experimental Design for the Life Sciences by : Graeme D. Ruxton

Download or read book Experimental Design for the Life Sciences written by Graeme D. Ruxton and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing students with clear and practical advice on how best to organise experiments and collect data so as to make the subsequent analysis easier and their conclusions more robust, this text assumes no specialist knowledge.

Landscapes and Labscapes

Author: Robert E. Kohler

Publisher: University of Chicago Press

Published: 2010-11-15

Total Pages: 341

ISBN-13: 0226450112

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What is it like to do field biology in a world that exalts experiments and laboratories? How have field biologists assimilated laboratory values and practices, and crafted an exact, quantitative science without losing their naturalist souls? In Landscapes and Labscapes, Robert E. Kohler explores the people, places, and practices of field biology in the United States from the 1890s to the 1950s. He takes readers into the fields and forests where field biologists learned to count and measure nature and to read the imperfect records of "nature's experiments." He shows how field researchers use nature's particularities to develop "practices of place" that achieve in nature what laboratory researchers can only do with simplified experiments. Using historical frontiers as models, Kohler shows how biologists created vigorous new border sciences of ecology and evolutionary biology.

Book Synopsis Landscapes and Labscapes by : Robert E. Kohler

Download or read book Landscapes and Labscapes written by Robert E. Kohler and published by University of Chicago Press. This book was released on 2010-11-15 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: What is it like to do field biology in a world that exalts experiments and laboratories? How have field biologists assimilated laboratory values and practices, and crafted an exact, quantitative science without losing their naturalist souls? In Landscapes and Labscapes, Robert E. Kohler explores the people, places, and practices of field biology in the United States from the 1890s to the 1950s. He takes readers into the fields and forests where field biologists learned to count and measure nature and to read the imperfect records of "nature's experiments." He shows how field researchers use nature's particularities to develop "practices of place" that achieve in nature what laboratory researchers can only do with simplified experiments. Using historical frontiers as models, Kohler shows how biologists created vigorous new border sciences of ecology and evolutionary biology.

Practical Statistics for Experimental Biologists

Author: Alastair C. Wardlaw

Publisher: Wiley

Published: 2000-04-07

Total Pages: 0

ISBN-13: 9780471988229

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A good working knowledge of statistical principles is needed for both the design and analysis of biological experiments and the subsequent handling of the large amounts of data generated if worthwhile, reliable conclusions are to be reached. Practical Statistics for Experimental Biologists, Second Edition provides biologists with a user-friendly, non-technical introduction to the basics of statistics. The book has been thoroughly revised and updated to incorporate: * Worked examples and printouts from MINITAB * Relevant case studies and applications * Further Notes section for background explanations Written by a biologist with extensive experience of applying statistical procedures to experimental systems, this book will be invaluable to undergraduates, postgraduates and researchers in microbiology, immunology, biochemistry, botany, zoology, physiology, pharmacology and pharmacy. Review of the First Edition "...strongly recommended as the current first choice both for students and established research workers." Society for General Microbiology Quarterly "...the book is refreshingly free from jargon, is well illustrated and is to be recommended." Trends in Biochemical Sciences "It is written in an easy style, and can be thoroughly recommended..." Trends in Pharmacological Sciences

Book Synopsis Practical Statistics for Experimental Biologists by : Alastair C. Wardlaw

Download or read book Practical Statistics for Experimental Biologists written by Alastair C. Wardlaw and published by Wiley. This book was released on 2000-04-07 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A good working knowledge of statistical principles is needed for both the design and analysis of biological experiments and the subsequent handling of the large amounts of data generated if worthwhile, reliable conclusions are to be reached. Practical Statistics for Experimental Biologists, Second Edition provides biologists with a user-friendly, non-technical introduction to the basics of statistics. The book has been thoroughly revised and updated to incorporate: * Worked examples and printouts from MINITAB * Relevant case studies and applications * Further Notes section for background explanations Written by a biologist with extensive experience of applying statistical procedures to experimental systems, this book will be invaluable to undergraduates, postgraduates and researchers in microbiology, immunology, biochemistry, botany, zoology, physiology, pharmacology and pharmacy. Review of the First Edition "...strongly recommended as the current first choice both for students and established research workers." Society for General Microbiology Quarterly "...the book is refreshingly free from jargon, is well illustrated and is to be recommended." Trends in Biochemical Sciences "It is written in an easy style, and can be thoroughly recommended..." Trends in Pharmacological Sciences

Collecting Experiments

Author: Bruno J. Strasser

Publisher: University of Chicago Press

Published: 2019-06-07

Total Pages: 421

ISBN-13: 022663518X

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Databases have revolutionized nearly every aspect of our lives. Information of all sorts is being collected on a massive scale, from Google to Facebook and well beyond. But as the amount of information in databases explodes, we are forced to reassess our ideas about what knowledge is, how it is produced, to whom it belongs, and who can be credited for producing it. Every scientist working today draws on databases to produce scientific knowledge. Databases have become more common than microscopes, voltmeters, and test tubes, and the increasing amount of data has led to major changes in research practices and profound reflections on the proper professional roles of data producers, collectors, curators, and analysts. Collecting Experiments traces the development and use of data collections, especially in the experimental life sciences, from the early twentieth century to the present. It shows that the current revolution is best understood as the coming together of two older ways of knowing—collecting and experimenting, the museum and the laboratory. Ultimately, Bruno J. Strasser argues that by serving as knowledge repositories, as well as indispensable tools for producing new knowledge, these databases function as digital museums for the twenty-first century.

Book Synopsis Collecting Experiments by : Bruno J. Strasser

Download or read book Collecting Experiments written by Bruno J. Strasser and published by University of Chicago Press. This book was released on 2019-06-07 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Databases have revolutionized nearly every aspect of our lives. Information of all sorts is being collected on a massive scale, from Google to Facebook and well beyond. But as the amount of information in databases explodes, we are forced to reassess our ideas about what knowledge is, how it is produced, to whom it belongs, and who can be credited for producing it. Every scientist working today draws on databases to produce scientific knowledge. Databases have become more common than microscopes, voltmeters, and test tubes, and the increasing amount of data has led to major changes in research practices and profound reflections on the proper professional roles of data producers, collectors, curators, and analysts. Collecting Experiments traces the development and use of data collections, especially in the experimental life sciences, from the early twentieth century to the present. It shows that the current revolution is best understood as the coming together of two older ways of knowing—collecting and experimenting, the museum and the laboratory. Ultimately, Bruno J. Strasser argues that by serving as knowledge repositories, as well as indispensable tools for producing new knowledge, these databases function as digital museums for the twenty-first century.

BIO2010

Author: National Research Council

Publisher: National Academies Press

Published: 2003-02-13

Total Pages: 208

ISBN-13: 0309085357

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Biological sciences have been revolutionized, not only in the way research is conductedâ€"with the introduction of techniques such as recombinant DNA and digital technologyâ€"but also in how research findings are communicated among professionals and to the public. Yet, the undergraduate programs that train biology researchers remain much the same as they were before these fundamental changes came on the scene. This new volume provides a blueprint for bringing undergraduate biology education up to the speed of today's research fast track. It includes recommendations for teaching the next generation of life science investigators, through: Building a strong interdisciplinary curriculum that includes physical science, information technology, and mathematics. Eliminating the administrative and financial barriers to cross-departmental collaboration. Evaluating the impact of medical college admissions testing on undergraduate biology education. Creating early opportunities for independent research. Designing meaningful laboratory experiences into the curriculum. The committee presents a dozen brief case studies of exemplary programs at leading institutions and lists many resources for biology educators. This volume will be important to biology faculty, administrators, practitioners, professional societies, research and education funders, and the biotechnology industry.

Book Synopsis BIO2010 by : National Research Council

Download or read book BIO2010 written by National Research Council and published by National Academies Press. This book was released on 2003-02-13 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological sciences have been revolutionized, not only in the way research is conductedâ€"with the introduction of techniques such as recombinant DNA and digital technologyâ€"but also in how research findings are communicated among professionals and to the public. Yet, the undergraduate programs that train biology researchers remain much the same as they were before these fundamental changes came on the scene. This new volume provides a blueprint for bringing undergraduate biology education up to the speed of today's research fast track. It includes recommendations for teaching the next generation of life science investigators, through: Building a strong interdisciplinary curriculum that includes physical science, information technology, and mathematics. Eliminating the administrative and financial barriers to cross-departmental collaboration. Evaluating the impact of medical college admissions testing on undergraduate biology education. Creating early opportunities for independent research. Designing meaningful laboratory experiences into the curriculum. The committee presents a dozen brief case studies of exemplary programs at leading institutions and lists many resources for biology educators. This volume will be important to biology faculty, administrators, practitioners, professional societies, research and education funders, and the biotechnology industry.

The Digital Cell

Author: Stephen J. Royle

Publisher:

Published: 2019

Total Pages: 200

ISBN-13: 9781621822783

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"Cell biology is becoming an increasingly quantitative field, as technical advances mean researchers now routinely capture vast amounts of data. This handbook is an essential guide to the computational approaches, image processing and analysis techniques, and basic programming skills that are now part of the skill set of anyone working in the field"--

Book Synopsis The Digital Cell by : Stephen J. Royle

Download or read book The Digital Cell written by Stephen J. Royle and published by . This book was released on 2019 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Cell biology is becoming an increasingly quantitative field, as technical advances mean researchers now routinely capture vast amounts of data. This handbook is an essential guide to the computational approaches, image processing and analysis techniques, and basic programming skills that are now part of the skill set of anyone working in the field"--